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It functions as a cofactor for lysyl oxidase (the enzyme responsible for collagen cross-linking and stabilization), ceruloplasmin (a copper transport protein with antioxidant activity), and superoxide dismutase (SOD, a primary antioxidant defense enzyme)

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Color changes in either lyophilized powder or reconstituted solution suggest chemical degradation

The cervicothoracic junction presents unique surgical challenges due to its anatomy

Activation of the coagulation system: This can lead to hypercoagulation and vascular blockage

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